Berkel, C., Keskin, A., & Cacan, E. (2025). Chemo-sensitive and chemo-resistant ovarian cancer cells show differences in cellular processes leading to pyroptotic cell death. Pathology, research and practice, 269, 155911. Advance online publication. https://doi.org/10.1016/j.prp.2025.155911    (Read this article)

Yilmaz, E., Yilmaz, D., Yildiz, C.G., & Cacan, E. (2025). Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19. Mol Biol Rep 52, 180 (2025). https://doi.org/10.1007/s11033-025-10289-6   (Read this article)

Caldiran, F., Menadi, S., Senol, R., & Cacan, E. (2025). The complex regulatory landscape of GSDMC and GSDMD mutations in colorectal cancer: A double-edged sword for survival outcomes. Human Gene, 44, 201391. https://doi.org/10.1016/j.humgen.2025.201391  (Read this article)

Yilmaz, E., Yilmaz, D., & Cacan, E. (2024). Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin. Scientific reports, 14(1), 29256. https://doi.org/10.1038/s41598-024-72192-7  (Read this article)

Caldiran, F., Deveci, K., & Cacan, E. (2024). Epigenetic insights into Familial Mediterranean Fever: Increased RGS10 expression and histone modifications accompany inflammation in familial Mediterranean fever disease. Gene, 906, 148222. https://doi.org/10.1016/j.gene.2024.148222  (Read this article)

Berkel C, Cacan E. Half of most frequently mutated genes in breast cancer are expressed differentially between premenopausal and postmenopausal breast cancer patients. Cancer Genet. 2024 Jun 13;286-287:11-17. doi: 10.1016/j.cancergen.2024.06.001.   (Read this article)

Kemel H, Benguedouar L, Boudjerda D, Menadi S, Cacan E, Sifour M. Phytochemical profiling, cytotoxic, anti-migration, and anti-angiogenic potential of phenolic-rich fraction from Peganum harmala: in vitro and in ovo studies. Med Oncol. 2024 May 8;41(6):144. doi: 10.1007/s12032-024-02396-4. PMID: 38717574.   (Read this article)

Berkel, C., & Cacan, E. (2024). A majority of circadian clock genes are expressed in estrogen receptor and progesterone receptor status-dependent manner in breast cancer. Journal of biosciences, 49, 80.   (Read this article)

Tapera, M., Kekeçmuhammed, H., Tüzün, B., Daştan, S.D., Çelik, M.S., Taslimi, P., Dastan, T., Topcu, K.S.B., Cacan, E., Şahin, O. and Sarıpınar, E., (2024). Novel 1, 2, 4-triazole-maleamic acid derivatives: synthesis and evaluation as anticancer agents with carbonic anhydrase inhibitory activity. Journal of Molecular Structure, 1313, 138680   (Read this article)

Menadi, S., Kucuk, B., & Cacan, E. (2024). Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis. Biochemical genetics, 10.1007/s10528-023-10577-5. https://doi.org/10.1007/s10528-023-10577-5   (Read this article)

Berkel, C., & Cacan, E. (2023). Lower expression of NINJ1 (Ninjurin 1), a mediator of plasma membrane rupture, is associated with advanced disease and worse prognosis in serous ovarian cancer. Immunologic research, 71(1), 15–28. https://doi.org/10.1007/s12026-022-09323-7  (Read this article)

Berkel, C., & Cacan, E. (2023). The expression of O-linked glycosyltransferase GALNT7 in breast cancer is dependent on estrogen-, progesterone-, and HER2-receptor status, with prognostic implications. Glycoconjugate journal, 10.1007/s10719-023-10137-4   (Read this article)

Caldiran, F., Senol, R., & Cacan, E. (2023). Epigenetic Regulation and Therapeutic Potential of Gasdermin Genes in Colorectal Adenocarcinoma. Experimed; 13(3): 218-256  (Read this article)

Caldiran, F., Berkel, C., Yilmaz, E., Kucuk, B., Cacan, A.H., Citli, S., Canpolat, E. & Cacan, E. (2023). Combination treatment of bortezomib and epirubicin increases the expression of TNFRSF10 A/B and induces TRAIL-mediated cell death in colorectal cancer cells. Biochemical and Biophysical Research Communications. Vol. 675. https://doi.org/10.1016/j.bbrc.2023.06.015  (Read this article)

Berkel, C., & Cacan, E. (2023). Pollutant-induced pyroptosis in humans and other animals. Life sciences, 121386. https://doi.org/10.1016/j.lfs.2023.121386 .  (Read this article)

Caldiran, F., Sahin, B., & Cacan, E. (2023). Serum acidic mammalian kinase as a new laboratory test to define subclinical inflammation in Familial Mediterranean fever. Experimental Biomedical Research, 6(3), 218-229. https://doi.org/https://doi.org/10.30714/j-ebr.2023.186    (Read this article)

Berkel, C., & Cacan, E. (2023). Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients. Reproductive sciences, https://doi.org/10.1007/s43032-023-01199-8  (Read this article)

Berkel, C., & Cacan, E. (2023). Trans-10, cis-12 conjugated linoleic acid- and caloric restriction-mediated upregulation of CNDP2 expression in white adipose tissue in rodents, with implications in feeding and obesity. The Journal of nutritional biochemistry, 109269. https://doi.org/10.1016/j.jnutbio.2023.109269 .  (Read this article)

Berkel, C., & Cacan, E. (2023). The influence of the host sex on parasitemia of parasite lineages belonging to Haemoproteus majoris in a natural bird community. Parasitology research, 10.1007/s00436-023-07793-8. https://doi.org/10.1007/s00436-023-07793-8 (Read this article)

Caldiran, F. Y., Deveci, K., & Cacan, E. (2022). NLRP13 inflammasome complex is hypermethylated in familial Mediterranean fever and global methylation correlates with the disease severity. Annals of human genetics, https://doi.org/10.1111/ahg.12493. (Read this article)

Kucuk, B., & Cacan, E. (2022). Expressional regulation of NKG2DLs is associated with the tumor development and shortened overall survival in lung adenocarcinoma. Immunobiology, 227(4), 152239. (Read this article)

Caldiran, F. Y., & Cacan, E. (2022). RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma. Pathology, research and practice, 236, 154007. (Read this article)

Berkel, C., & Cacan, E. (2022). Intersexual differences in the number of genes differentially expressed in wild mammals in response to predation risk. Physiology & behavior, 255, 113920. (Read this article)

Berkel, C. & Cacan, E. (2022). Epithelial tumor compartment- and adjacent stromal compartment-specific expression of PARP1 in different anatomical sites in patients with HGSOC. Genome Instability and Disease. (Read this article)

Caldiran, F. Y., Berkel, C., Deveci, K., & Cacan E. (2022). In silico analysis of expression and DNA methylation profiles of NLRP13 Inflammasome in tumor cells. Human Gene, 33. (Read this article)

Berkel, C., & Cacan E. (2022). DYNLL1 transcript abundance decreases during oocyte and follicular growth and is associated with fertility in mice. Genome Instability and Disease, https://doi.org/10.1007/s42764-022-00096-9 (Read this article)

Sekrani, I., Ameddah, S., Benrebaia, M., Bouaroudge, A., Erenler, R., Benkiniouar, R., Cacan, E., & Menad, A. (2022). Algerian Capparis spinosa n-BuOH Extract Alleviates Diabetic Neuropathy Induced with Streptozotocin in Rats. Egyptian Journal of Chemistry, doi: 10.21608/ejchem.2022.156714.6790. (Read this article)

Berkel, C., & Cacan, E. (2022). Sex-specific changes in the expression of ER-alpha and androgen receptor with increasing tumor grade in patients with hepatocellular carcinoma. Human cell, 35(3), 948–951. (Read this article)

Berkel, C., & Cacan, E. (2022). Copy number and expression of CEP89, a protein required for ciliogenesis, are increased and predict poor prognosis in patients with ovarian cancer. Cell biochemistry and function, 40(3), 298–309. (Read this article)

Saidi, A., Hambaba, L., Kucuk, B., Cacan & Erenler, R. (2022). Phenolic profile, acute toxicity, and hepatoprotective and antiproliferative activities of Algerian Ruta tuberculata Forssk. Current Bioactive Compounds, 18(3), 72-83. (Read this article)

Kucuk, B., Yilmaz, E., & Cacan, E. (2021). Expression profiles of Natural Killer Group 2D Ligands (NGK2DLs) in colorectal carcinoma and changes in response to chemotherapeutic agents. Molecular biology reports, 48(5), 3999–4008. (Read this article)

Berkel, C., & Cacan, E. (2021). Differential Expression and Copy Number Variation of Gasdermin (GSDM) Family Members, Pore-Forming Proteins in Pyroptosis, in Normal and Malignant Serous Ovarian Tissue. Inflammation, 44(6), 2203–2216. (Read this article)

Berkel, C., & Cacan, E. (2021). Involvement of ATMIN-DYNLL1-MRN axis in the progression and aggressiveness of serous ovarian cancer. Biochemical and biophysical research communications, 570, 74–81.(Read this article)

Caldiran, F.Y., Citli, S., Cacan, E., & Deveci, K. (2021). Evaluation of IL-1β, IL-18 and Caspase-1 Levels in Familial Mediterranean Fever Patients with Attack and Remission Period. Journal of Contemporary Medicine, 11(4), 494-499. (Read this article)

Berkel, C., & Cacan, E. (2021). Estrogen- and estrogen receptor (ER)-mediated cisplatin chemoresistance in cancer. Life sciences, 286, 120029. (Read this article)

Karatas, O., Yuce, H. B., Taskan, M. M., Gevrek, F., Yarkac, F. U., & Cacan, E. (2021). Detection of nuclear receptors in gingival samples of diabetic and nondiabetic periodontitis patients. Nigerian journal of clinical practice, 24(2), 269–276. (Read this article)

Saygi, K. O., & Cacan, E. (2021). Antioxidant and cytotoxic activities of silver nanoparticles synthesized using Tilia cordata flowers extract. Materials Today Communications, 27(2021). (Read this article)

Berkel, C., & Cacan, E. (2021). Metastases from metastases: comparative metastatic potential of human cancer cell lines originated from primary tumors or metastases in various tissues. Journal of cell communication and signaling, 15(3), 461–464. (Read this article)

Berkel, C., & Cacan, E. (2021). A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds. Biogerontology, 22(6), 639–653. (Read this article)

Kucuk, B., Kibar, B., & Cacan, E. (2021). A broad analysis in clinical and in vitro models on regulator of G-protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance. Cell biochemistry and function, 39(3), 413–422. (Read this article)

Berkel, C., & Cacan, E. (2021). Transcriptomic analysis reveals tumor stage- or grade-dependent expression of miRNAs in serous ovarian cancer. Human cell, 34(3), 862–877. (Read this article)

Berkel, C., & Cacan, E. (2021). GAB2 and GAB3 are expressed in a tumor stage-, grade- and histotype-dependent manner and are associated with shorter progression-free survival in ovarian cancer. Journal of cell communication and signaling, 15(1), 57–70. (Read this article)

Berkel, C., & Cacan, E. (2021). Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans. Biogerontology, 22(3), 329–343. (Read this article)

Aissous, I., Benrebai, M., Cacan, E.,, Berkel, C., Erenler, R., Ameddah, S., Benayache, S., Benayache, F., Bensouici, C. (2021). Antioxidant And Antiproliferative Activities Of The N-Butanol Extract Of Centaurea Maroccana Ball Aerial Parts, Current Issues İn Pharmacy And Medical Sciences, 34(1), 5-11. (Read this article)

Kocak, A., Kisa, D., Yilmaz, N., & Cacan, E. (2021).  Investigation of some antioxidant enzyme activities in an experimental colon cancer rat model. MAS Journal of Applied Science, 6(5).  (Read this article)

Hadjira, S. ,Mansour, A., Berkel, C., Seghiri, R., Menad, A., Benayache, F., Benayache, S., Cacan, E., Ameddah, S. (2021). Antioxidant, Anti-Inflammatory And Cytotoxic Properties Of Centaurea Africana Lamk Var. [Bonnet] M, Anti-Inflammatory &Amp; Anti-Allergy Agents İn Medicinal Chemistry, 20(1), 89-100. (Read this article)

Berkel, C., & Cacan, E. (2020). DYNLL1 is hypomethylated and upregulated in a tumor stage- and grade-dependent manner and associated with increased mortality in hepatocellular carcinoma. Experimental and molecular pathology, 117, 104567. (Read this article)

Berkel, C., Kucuk, B., Usta, M., Yilmaz, E., Cacan, E. (2020). The Effect Of Olaparib And Bortezomib Combination Treatment On Ovarian Cancer Cell Lines, European Journal Of Biology, 79(2), 115-123. (Read this article)

Berkel, C., & Cacan, E. (2020). In silico analysis of DYNLL1 expression in ovarian cancer chemoresistance. Cell biology international, 44(8), 1598–1605. (Read this article)

AlJanabi Ahmed S M, Alheety Mustafa A, AlSamrai Osamaa A Y, Shaaban Saad, Kibar Beyza, Cacan Ercan, (2020). "Anti-Cancer And Anti-Fungal Evaluation Of Novel Palladium(Iı) 1-Phenyl-1H-Tetrazol-5-Thiol Complexes", Inorganic Chemistry Communıcations. (Read this article)

Cacan, E., & Ozmen, Z. C. (2020). Regulation of Fas in response to bortezomib and epirubicin in colorectal cancer cells. Journal of chemotherapy (Florence, Italy), 32(4), 193–201. (Read this article)

Berkel, C., & Cacan, E. (2019). Single-Cell Epigenomics in Cancer Research. Biomedical Journal of Scientific & Technical Research. 21(3), 15966-15973. (Read this article)

Cacan E. (2017). Epigenetic-mediated immune suppression of positive co-stimulatory molecules in chemoresistant ovarian cancer cells. Cell biology international, 41(3), 328–339.  (Read this article)

Alqinyah, M., Maganti, N., Ali, M. W., Yadav, R., Gao, M., Cacan, E., Weng, H. R., Greer, S. F., & Hooks, S. B. (2017). Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. Molecular pharmacology, 91(3), 197–207. (Read this article)

Cacan E. (2017). Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells. Journal of chemotherapy (Florence, Italy), 29(3), 173–178.  (Read this article)

Gülmez, Y., Aydın, A., Can, İ., Tekin, Ş., & Cacan, E. (2017). Cellular toxicity and biological activities of honey bee (Apis mellifera L.) venom. Marmara Pharmaceutical Journal, 21(2), 251-260.  (Read this article)

Cacan, E. (2017). Enhancing sensitivity of chemoresistant ovarian cancer cells to TRAIL and FAS mediated apoptosis by radiation. Turkish Bulletin of Hygiene & Experimental Biology/Türk Hijyen ve Deneysel Biyoloji, 74(3).  (Read this article)

Ding, Z. C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H., & Zhou, G. (2016). IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells. Oncoimmunology, 5(6), e1171445. https://doi.org/10.1080/2162402X.2016.1171445  (Read this article)

Cacan E. (2016). Histone Deacetylase-1-mediated Suppression of FAS in Chemoresistant Ovarian Cancer Cells. Anticancer research, 36(6), 2819–2826.  (Read this article)

Cacan, E., Greer, S. F., & Garnett-Benson, C. (2015). Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. International journal of oncology, 47(6), 2264–2275.  (Read this article)

Morgan, J. E., Shanderson, R. L., Boyd, N. H., Cacan, E., & Greer, S. F. (2015). The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination. Bioscience reports, 35(4), e00233.  (Read this article)

Cacan, E., Spring, A. M., Kumari, A., Greer, S. F., & Garnett-Benson, C. (2015). Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack. International journal of molecular sciences, 16(12), 30405–30421.  (Read this article)

Cacan, E., Ali, M. W., Boyd, N. H., Hooks, S. B., & Greer, S. F. (2014). Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance. PloS one, 9(1), e87455. (Read this article)

Ali, M. W., Cacan, E., Liu, Y., Pierce, J. Y., Creasman, W. T., Murph, M. M., Govindarajan, R., Eblen, S. T., Greer, S. F., & Hooks, S. B. (2013). Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells. PloS one, 8(3), e60185. (Read this article)

Cacan, E., Kratzer, J. T., Cole, M. F., & Gaucher, E. A. (2013). Interchanging functionality among homologous elongation factors using signatures of heterotachy. Journal of molecular evolution, 76(1-2), 4–12. (Read this article)

Kumari, A., Cacan, E., Greer, S. F., & Garnett-Benson, C. (2013). Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells. Journal for immunotherapy of cancer, 1, 17. (Read this article)